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 CASE REPORT
CytoJournal 2005,  2:6

Desmoplastic small round cell tumour : Cytological and immunocytochemical features


1 Pathology Department, School of Medicine, São Paulo University, São Paulo, Brazil
2 Department of Pathology and Treatment and Research Center of A.C. Camargo Hospital, São Paulo, Brazil
3 Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal; Pathology Division, Adolfo Lutz Institute, São Paulo, Brazil
4 Medical Faculty, Department of Pathology, University of Porto, Porto, Portugal; IPATIMUP – Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal

Correspondence Address:
Fernando C Schmitt
Medical Faculty, Department of Pathology, University of Porto, Porto, Portugal; IPATIMUP – Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal

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Source of Support: None, Conflict of Interest: None


DOI: 10.1186/1742-6413-2-6

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Background: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological features quite similar to other small round blue cells tumors. We described four cases of DSRCT with cytological sampling: one obtained by fine needle aspiration biopsy (FNAB) and three from serous effusions. The corresponding immunocytochemical panel was also reviewed. Methods: Papanicolaou stained samples from FNAB and effusions were morphologically described. Immunoreaction with WT1 antibody was performed in all cytological samples. An immunohistochemical panel including the following antibodies was performed in the corresponding biopsies: 34BE12, AE1/AE3, Chromogranin A, CK20, CK7, CK8, Desmin, EMA, NSE, Vimentin and WT1. Results: The smears showed high cellularity with minor size alteration. Nuclei were round to oval, some of them with inconspicuous nucleoli. Tumor cells are clustered, showing rosette-like feature. Tumor cells in effusions and FNA were positive to WT1 in 3 of 4 cytology specimens (2 out 3 effusions and one FNA). Immunohistochemical reactions for vimentin, NSE, AE1/AE3 and WT1 were positive in all cases in tissue sections. Conclusion: The use of an adjunct immunocytochemical panel coupled with the cytomorphological characteristics allows the diagnosis of DSRCT in cytological specimens.






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